Study Description: The purpose of this study is to see if the drug, CPI-1205, in combination with standard of care treatments enzalutamide or abiraterone/prednisone can improve conditions for males with metastatic castration resistant prostate cancer. The study is designed to determine the best dose for CPI-1205.

Eligibility:

Inclusion Criteria:

Adults (Age ≥ 18 years)

Metastatic prostate cancer

Must have undergone surgical or medical castration

Progressive disease in the setting of medical or surgical castration (i.e. CRPC) as defined by elevated PSA AND/OR progression based on bone scan or CT scan

Serum testosterone <50 ng/dL

Prior hormonal treatment for metastatic disease

Demonstrate adequate organ function

Exclusion Criteria:

Known symptomatic brain metastases

Clinically significant cardiovascular disease

Active viral hepatitis or chronic liver disease

GI disorder that negatively affects absorption

Any other ongoing severe and/or uncontrolled medical condition